Estrogen Inhibits Bone Resorption by Directly Inducing Apoptosis of the Bone-resorbing Osteoclasts

نویسندگان

  • Takashi Kameda
  • Hiroshi Mano
  • Tatsuhisa Yuasa
  • Yoshihisa Mori
  • Koshi Miyazawa
  • Miho Shiokawa
  • Yukiya Nakamaru
  • Emi Hiroi
  • Kenji Hiura
  • Akira Kameda
  • Na N. Yang
  • Yoshiyuki Hakeda
  • Masayoshi Kumegawa
چکیده

Estrogen deficiency causes bone loss, which can be prevented by estrogen replacement therapy. Using a recently developed technique for isolation of highly purified mammalian osteoclasts, we showed that 17 beta-estradiol (E2) was able to directly inhibit osteoclastic bone resorption. At concentrations effective for inhibiting bone resorption, E2 also directly induced osteoclast apoptosis in a dose- and time-dependent manner. ICI164,384 and tamoxifen, as pure and partial antagonists, respectively, completely or partially blocked the effect of E2 on both inhibition of osteoclastic bone resorption and induction of osteoclast apoptosis. These data suggest that the protective effects of estrogen against postmenopausal osteoporosis are mediated in part by the direct induction of apoptosis of the bone-resorbing osteoclasts by an estrogen receptor- mediated mechanism.

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عنوان ژورنال:
  • The Journal of Experimental Medicine

دوره 186  شماره 

صفحات  -

تاریخ انتشار 1997